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Postinflammatory hyperpigmentation: A comprehensive overview: Treatment options and prevention.

Suteeraporn Chaowattanapanit1, Narumol Silpa-Archa2, Indermeet Kohli3

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Postinflammatory hyperpigmentation (PIH) is a common skin condition that can be prevented or treated. Addressing underlying inflammation is key, followed by considering specific treatments for PIH.

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Area of Science:

  • Dermatology
  • Pathophysiology
  • Medical Education

Background:

  • Postinflammatory hyperpigmentation (PIH) arises after skin inflammation or injury.
  • PIH presents a chronic, unpredictable course, with epidermal PIH generally resolving better than dermal PIH.
  • Effective management necessitates understanding PIH causes and treatment options.

Purpose of the Study:

  • To review evidence supporting medical and procedural treatments for PIH.
  • To present a reproducible model for PIH research.
  • To provide a clinical practice algorithm and discuss PIH prevention.

Main Methods:

  • Literature review of medical and procedural treatments for PIH.
  • Description of a reproducible PIH model.
  • Development of a clinical algorithm for PIH management.

Main Results:

  • Evidence supports various treatments for PIH, with varying efficacy for epidermal versus dermal types.
  • A reproducible PIH model is crucial for advancing treatment development.
  • An integrated approach involving treating underlying inflammation and targeted PIH therapies is recommended.

Conclusions:

  • Prompt identification and treatment of underlying inflammatory causes are essential for managing PIH.
  • Specific medical and procedural treatments, guided by a clinical algorithm, can alleviate PIH.
  • Prevention strategies and a deeper understanding of PIH pathophysiology are vital for improved patient outcomes.