Liver transplantation in children: state of the art and future perspectives
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Published on: September 22, 2023
Rohit Kohli1, Miriam Cortes2, N D Heaton2
1Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Children's Hospital Los Angeles, Los Angeles, California, USA.
Insights
Pediatric liver transplantation is a complex, lifelong process requiring adherence to immunosuppression and lifestyle changes. This review details surgical advances and potential complications for children undergoing liver transplants.
Area of Science:
- Pediatric Gastroenterology and Hepatology
- Surgical Innovation
- Transplant Medicine
Background:
- Liver transplantation in children has been performed for over 30 years.
- Pediatric specialists collaborate with transplant centers to manage these patients.
- Understanding the comprehensive journey of pediatric liver transplant recipients is crucial.
Purpose of the Study:
- To provide a state-of-the-art review of pediatric liver transplantation.
- To enhance understanding of the child and family's experience.
- To detail surgical advancements and potential complications.
Main Methods:
- Review of current literature and clinical practices in pediatric liver transplantation.
- Analysis of surgical techniques and outcomes.
- Discussion of immediate and long-term follow-up care.
Main Results:
- Liver transplantation in children is an ongoing management strategy, not a definitive cure.
- Successful transplantation requires strict adherence to immunosuppressive therapy.
- Lifelong medical follow-up and healthy lifestyle are essential for long-term outcomes.
Conclusions:
- Pediatric liver transplantation involves significant surgical advancements.
- Patients face potential immediate and long-term complications.
- Lifelong management, including immunosuppression and lifestyle, is critical for success.
Abstract:
In this review, we provide a state of the art of liver transplantation in children, as the procedure is now carried out for more than 30 years and most of our paediatric colleagues are managing these patients jointly with liver transplant centres. Our goal for this article is to enhance the understanding of the liver transplant process that a child and his family goes through while explaining the surgical advances and the associated complications that could happen in the immediate or long-term follow-up. We have deliberately introduced the theme that 'liver transplant is a disease' and 'not a cure', to emphasise the need for adherence with immunosuppression, a healthy lifestyle and lifelong medical follow-up.
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