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Published on: June 17, 2025
Primary inflammatory myofibroblastic tumor of the diaphragm: Report of a case
Junke Fu1, Qifei Wu1, Yong Zhang1
1Department of Thoracic Surgery, the First Affiliated Hospital of Medical Collage, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China Department of Hepatobiliary Surgery, the First Affiliated Hospital of Medical Collage, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.
Abstract:
We report a case of primary inflammatory myofibroblastic tumor of the diaphragm in a 64-year-old man. The patient was hospitalized for a computed tomography (CT)-detected large tissue mass at the left lower lung field. Complete tumor excision followed by pathological investigation was performed. Microscopically, the tumor showed staggered arrangements of spindle myoepithelial cells, lymphoblastic and eosinophil cells. Immunohistochemically, the proliferating spindle cells showed positive staining for smooth muscle actin, vimentin, CD68 and Desmin, but negative for cytokeratin, leukocyte common antigen, epithelial membrane antigen, and S-100. This is the first reported inflammatory myofibroblastic tumor of the diaphragm found in an adult. The postoperative course was uneventful and the patient had no recurrence 18 months after surgery.
