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Overview Of Cell Separation And Isolation

Overview Of Cell Separation And Isolation

Cell separation was first achieved in 1964 by S. H. Seal, who separated large tumor cells from the smaller blood cells using filtration. Two years later, Pohl and Hawk performed experiments on how cells respond differently to a nonuniform electric field based on the cell type. Such observations were the inception of cell separation methods, which allow isolating a single cell type from a heterogeneous sample.

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Updated: Feb 22, 2026

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Microbial separation from a complex matrix by a hand-held microfluidic device.

Renu Singh¹, John Brockgreitens, Olga Saiapina

¹Department of Bioproducts and Biosystems Engineering, University of Minnesota St. Paul, MN 55108-6005, USA. aabbas@umn.edu.

Chemical Communications (Cambridge, England)

|September 19, 2017

Summary

This summary is machine-generated.

Researchers developed a simple chemical method to rapidly isolate microorganisms from samples. This technique uses gold-coated surfaces in a microfluidic device, achieving over 99% capture efficiency for bacteria and fungi.

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Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering

Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering

Published on: July 10, 2016

Area of Science:

Biotechnology
Microbiology
Analytical Chemistry

Background:

Microorganism isolation is crucial for diagnostics and research.
Current methods can be time-consuming and inefficient.
Need for rapid, high-efficiency capture techniques.

Purpose of the Study:

To develop a rapid and efficient method for microorganism isolation.
To enable selective capture and concentration of bacteria and fungi.
To facilitate downstream analysis of captured microbial cells.

Main Methods:

Chemical activation of microbial cell surface biomolecules.
Utilizing gold-coated surfaces within a microfluidic device.
Selective capture, concentration, and retrieval of microorganisms.

Main Results:

Achieved over 99% capture efficiency for microorganisms.
Demonstrated selective isolation of bacterial and fungal cells.
Rapid isolation and concentration of target microbes.

Conclusions:

The developed method offers a highly efficient and rapid approach for microorganism isolation.
This technique is suitable for selective capture and concentration of diverse microbial types.
Enables streamlined sample preparation for further microbial analysis.