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The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
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Related Experiment Video

Updated: Feb 22, 2026

Assessing Pupil-linked Changes in Locus Coeruleus-mediated Arousal Elicited by Trigeminal Stimulation
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[Mind your teeth - the relationship between mastication and cognition].

R A F Weijenberg, S Delwel, B V Ho

    Nederlands Tijdschrift Voor Tandheelkunde
    |September 19, 2017
    PubMed
    Summary

    Elderly individuals with dementia face higher risks of oral health issues. Cognitive decline may impact self-care, while mastication

    Area of Science:

    • Gerontology
    • Neuroscience
    • Oral Health

    Background:

    • Elderly individuals, particularly those with dementia, exhibit increased susceptibility to oral health problems, including orofacial pain and tooth loss.
    • Cognitive and motor impairments associated with dementia may lead to reduced self-care, exacerbating oral health decline.
    • A bidirectional relationship between cognition and oral health is hypothesized, suggesting mutual influence.

    Purpose of the Study:

    • To explore the complex relationship between oral health and cognitive function in the elderly, especially those with dementia.
    • To investigate potential mechanisms linking cognitive decline, self-care, and oral health status.
    • To review existing evidence on the impact of mastication on cognitive function.

    Main Methods:

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  • Review of existing literature on dementia, oral health, and cognitive function.
  • Analysis of animal studies investigating the effects of masticatory activity on memory and neuronal health.
  • Examination of human studies exploring the link between mastication and cognition.
  • Main Results:

    • Animal studies indicate that reduced masticatory activity can lead to memory loss and neuronal degeneration.
    • Human studies suggest a connection between mastication and cognition, but a definitive cause-effect relationship remains unclear.
    • Multiple factors, including self-care, nutrition, stress, and pain, likely mediate the oral health-cognition relationship.

    Conclusions:

    • The interplay between oral health and cognitive function in the elderly is multifactorial.
    • Further research is needed to elucidate the causal pathways between mastication, cognition, and overall health in dementia patients.
    • Interventions targeting oral self-care and nutrition may be beneficial for both oral and cognitive health in this population.