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Updated: Feb 22, 2026

Thermal Preconditioning During Ex-vivo Lung Perfusion for the Rehabilitation of Damaged Lung Grafts before Transplantation
Published on: October 31, 2025
Preoperative estimation of pulmonary extravascular thermal volume in patients undergoing pneumonectomy
Tsutomu Sakuma1, Tasuku Nakada1, Kaoru Koike2
1Department of Surgery, Sendai Kosei Hospital, 4-12 Hirosemachi, Aobaku, 980, Sendai, Japan.
Abstract:
Pulmonary extravascular thermal volume (PETV) was measured during pulmonary artery occlusion in 18 patients preoperatively and 7 patients postoperatively who were undergoing pneumonectomy. We found that the PETV decreased from 6.6±2.3 ml·kg-1 before occlusion to 4.1±1.6 ml·kg-1 during occlusion. There was a significant correlation between the PETVs before and during occlusion multiplied by the fraction of pulmonary perfusion (r=0.77,P<0.001). Although the PETV increased in two patients and decreased in four within 48 h after pneumonectomy, it returned to the value during occlusion at 3 weeks after pneumonectomy in seven patients. There was a significant correlation between the PETV during occlusion and that at 3 weeks after pneumonectomy (r=0.66,P<0.05). In conclusion, PETV during pulmonary artery occlusion is a reliable baseline value in the assessment of postoperative pneumonectomy values.
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