Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Robotic recipient liver transplantation worldwide: a systematic review and meta-analysis of the first 93 patients, from feasibility to early outcomes.

EClinicalMedicine·2026

Same author

Reply to Dion et al. Comment on "Sun et al. First Experience with Hypothermic Oxygenated Perfusion in Human Uteri: Feasibility and Metabolic Characterization. <i>J. Clin. Med.</i> 2026, <i>15</i>, 2820".

Journal of clinical medicine·2026

Same author

Donor obesity and MASLD as barriers to living donor liver transplantation: Institutional attrition and national outcomes.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2026

Same author

Portal-Venous Hypothermic Oxygenated Perfusion for Liver Transplant: A Randomized Clinical Trial.

JAMA surgery·2026

Same author

Fluorescence spectroscopy precorrection model robust to large variability of optical properties: application to point of care quantitative liver graft viability assessment.

Biomedical optics express·2026

Same author

A diagnostic accuracy study of mitochondrial FMN during hypothermic oxygenated perfusion to guide liver utilization and avoid normothermic assessment.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2026

Same journal

Introduction to pediatric solid organ transplantation - not just little adults!

Current opinion in organ transplantation·2026

Same journal

Editorial introduction.

Current opinion in organ transplantation·2026

Same journal

Precision medicine guided development of new immunosuppression strategies in solid organ transplantation.

Current opinion in organ transplantation·2026

Same journal

Intestinal transplantation for tumors.

Current opinion in organ transplantation·2026

Same journal

Current state of medical rehabilitation for adult short bowel syndrome patients with intestinal failure.

Current opinion in organ transplantation·2026

Same journal

Update on costimulatory blockade in transplantation: a review of recent literature.

Current opinion in organ transplantation·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Feb 22, 2026

Ex Situ Normothermic Machine Perfusion of Donor Livers

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

Hypothermic liver perfusion.

Andrea Schlegel¹, Xavier Muller, Philipp Dutkowski

¹aThe Liver Unit, Queen Elizabeth Hospital Birmingham bNIHR Liver Biomedical Research Unit, University Hospitals Birmingham, Birmingham, United Kingdom cDepartment of Surgery and Transplantation, University Hospital Zurich, Zürich, Switzerland.

Current Opinion in Organ Transplantation

|September 19, 2017

Summary

This summary is machine-generated.

Hypothermic machine perfusion is a new technique improving liver preservation. It shows promise in reducing complications, especially for high-risk donor livers, potentially expanding donor acceptance criteria.

More Related Videos

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Published on: August 13, 2014

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

Related Experiment Videos

Last Updated: Feb 22, 2026

Ex Situ Normothermic Machine Perfusion of Donor Livers

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Technique of Subnormothermic Ex Vivo Liver Perfusion for the Storage, Assessment, and Repair of Marginal Liver Grafts

Published on: August 13, 2014

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

Area of Science:

Hepatology
Transplantation Medicine
Organ Preservation

Background:

Maximizing the use of donor livers is crucial in transplantation.
New machine preservation techniques are being explored to improve graft utilization.
Hypothermic machine perfusion (HMP) is emerging as a clinical tool.

Purpose of the Study:

To review recent advancements in hypothermic machine liver perfusion.
To focus on the protective mechanisms of HMP.
To evaluate HMP's role in high-risk donor-recipient scenarios.

Main Methods:

Review of current clinical studies and case series on HMP.
Detailed description of a specific HMP approach.
Analysis of reperfusion injury and protection pathways.

Main Results:

HMP is being investigated in clinical trials for liver transplantation.
Case series show promising results in preventing biliary complications, particularly with extended criteria donor grafts.
HMP may enable wider acceptance of high-risk donor livers.

Conclusions:

HMP is a developing technique with potential to improve liver transplant outcomes.
The review details HMP concepts, clinical results, and implementation.
Future aspects and impact on clinical scenarios are discussed.