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Published on: September 8, 2014
A Redox Modulatory Mn3 O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a
Namrata Singh1,2,3, Mohammed Azharuddin Savanur2, Shubhi Srivastava2
1Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore-, 560012, India.
Abstract:
Nanomaterials with enzyme-like activities (nanozymes) attracts significant interest due to their therapeutic potential for the treatment of various diseases. Herein, we report that a Mn3 O4 nanozyme functionally mimics three major antioxidant enzymes, that is, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the multienzyme activity is size as well as morphology-dependent. The redox modulatory effect of Mn3 O4 plays a crucial role in protecting the cells from MPP+ induced cytotoxicity in a Parkinson disease (PD)-like cellular model, indicating that manganese-based nanomaterials having multi-enzyme activity can robustly rescue the cells from oxidative damage and thereby possess therapeutic potential to prevent ROS-mediated neurological disorders.
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