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Related Concept Videos

Translation01:31

Translation

18.4K
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are...
18.4K
Translation01:31

Translation

157.8K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
157.8K
Leaky Scanning02:28

Leaky Scanning

5.8K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.8K
Ribosome Profiling02:24

Ribosome Profiling

4.2K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.2K
Ribosomes01:27

Ribosomes

78.4K
Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome...
78.4K
Ribosomes01:27

Ribosomes

11.3K
Ribosomes translate genetic information encoded by messenger RNA (mRNA) into proteins. Both prokaryotic and eukaryotic cells have ribosomes. Cells that synthesize large quantities of protein—such as secretory cells in the human pancreas—can contain millions of ribosomes.
Ribosome Structure and Assembly
Ribosomes are composed of ribosomal RNA (rRNA) and proteins. In eukaryotes, rRNA is transcribed from genes in the nucleolus—a part of the nucleus that specializes in ribosome...
11.3K

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Related Experiment Video

Updated: Feb 22, 2026

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
10:24

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources

Published on: January 27, 2026

273

How Ribosomes Translate Cancer.

Sergey O Sulima1, Isabel J F Hofman1, Kim De Keersmaecker2

  • 1Department of Oncology, KU Leuven, University of Leuven, LKI, Leuven Cancer Institute, Leuven, Belgium.

Cancer Discovery
|September 20, 2017
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Summary

Ribosomes, crucial for protein synthesis, are increasingly implicated in cancer development. Targeting these "onco-ribosomes" presents a promising new therapeutic strategy for cancer treatment.

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Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling
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Related Experiment Videos

Last Updated: Feb 22, 2026

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
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Assessment of Selective mRNA Translation in Mammalian Cells by Polysome Profiling
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Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Ribosomes are essential for protein synthesis.
  • Novel findings link ribosomal mutations to ribosomopathies and cancers.
  • Understanding ribosome's role in oncogenesis is rapidly evolving.

Purpose of the Study:

  • To explore mechanisms of ribosome involvement in carcinogenesis.
  • To discuss how ribosome defects contribute to cancer progression.
  • To highlight therapeutic strategies targeting ribosomes.

Main Methods:

  • Review of current literature on ribosomal mutations and cancer.
  • Analysis of molecular mechanisms linking ribosomes to oncogenesis.
  • Discussion of clinical implications and therapeutic interventions.

Main Results:

  • Ribosomes are hijacked by oncogenic factors.
  • Dysregulated translational control impacts cancer.
  • Ribosomal mutations affect cellular metabolism.
  • Somatic mutations in ribosomal proteins are found in cancers.

Conclusions:

  • Ribosomes play a significant role in cancer development.
  • "Onco-ribosomes" represent a vulnerability in cancer cells.
  • Targeting ribosomes offers a promising therapeutic avenue.