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Updated: Feb 22, 2026
In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
Laser-Induced Choroidal Neovascularizations: Clinical Study of 3 Cases
Wipada Laovirojjanakul1, Thuss Sanguansak1, Yosanan Yospaiboon1
1Department of Ophthalmology, KKU Eye Center, Khon Kaen University, Khon Kaen, Thailand.
Background:
We report 3 patients with laser-induced choroidal neovascularization (CNV).
Method:
Retrospective, observational case series. Medical charts and photographs were reviewed.
Results:
Two patients with central serous chorioretinopathy who developed iatrogenic CNV after focal laser photocoagulation were treated with intravitreal ranibizumab injections. One patient with CNV secondary to thermal laser photocoagulation for diabetic macular edema was treated with photodynamic therapy (PDT). Visual improvement has been demonstrated in the patients treated with intravitreal ranibizumab injections, and their successful visual outcome was stable for more than 2 years. Stable visual acuity was also observed in the patient treated with PDT, no visual improvement was observed possibly due to the macular scar and macular ischemia. No systemic or ocular complications were detected among the 3 cases.
Conclusion:
To prevent a laser-induced CNV, it is critical to avoid heavy small-spot laser burns and repeated application. Patients should be monitored carefully for CNV after laser treatment. In our cases, PDT and intravitreal ranibizumab injections were effective for the treatment of laser-induced CNV.
