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Decrease of the salt appetite of spontaneously hypertensive rats by chronic application of almitrine
Biomedica Biochimica Acta
|January 1, 1987
Summary
Almitrine effectively reduced salt appetite and water intake in spontaneously hypertensive rats. Peripheral arterial chemoreceptor activity is crucial for maintaining salt intake in these hypertensive rats.
Area of Science:
- Physiology
- Pharmacology
- Nephrology
Background:
- Spontaneously hypertensive rats (SHR) exhibit altered salt appetite and water intake.
- Peripheral arterial chemoreceptors are implicated in cardiovascular regulation.
Purpose of the Study:
- To investigate the effects of almitrine on salt appetite, water intake, and renal function in SHR.
- To explore the role of peripheral arterial chemoreceptors in salt intake regulation in SHR.
Main Methods:
- Conscious adult male and female SHR were used.
- Almitrine was administered orally at 0.4 mg/kg for five days.
- Salt and water intake, and renal electrolyte excretion were monitored.
Main Results:
- Almitrine significantly suppressed voluntary salt intake and temporarily decreased water intake.
- Renal electrolyte excretion patterns correlated with intake patterns.
- These findings suggest a role for peripheral arterial chemoreceptors.
Conclusions:
- Almitrine's effects on salt and water intake highlight its physiological impact.
- Peripheral arterial chemoreceptor activity is essential for maintaining salt appetite in SHR.
- This study provides insights into the neuro-renal mechanisms governing salt intake in hypertension.