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Interaction between amphetamine and alpha 2-postsynaptic adrenoreceptors in the rat submaxillary gland
J C Elverdin1, M L Fiszman, F J Stefano
1Cátedra de Fisiología, Facultad de Odontología, Universidad de Buenos Aires, Argentina.
Journal of Autonomic Pharmacology
|September 1, 1987
Summary
Amphetamine directly interacts with alpha 2-adrenoreceptor agonists, blocking their inhibitory effects on rat submaxillary gland secretions. This interaction is independent of amphetamine
Area of Science:
- Pharmacology
- Neuroscience
- Physiology
Background:
- Alpha 2-adrenoreceptor agonists like clonidine and guanabenz inhibit salivation.
- Amphetamine's effects on these pathways are not fully understood.
Purpose of the Study:
- To investigate the interaction between amphetamine and alpha 2-adrenoreceptor agonists in regulating salivary secretion.
- To determine if amphetamine directly interacts with postsynaptic alpha 2-adrenoreceptors.
Main Methods:
- Studied the effects of clonidine, guanabenz, and amphetamine on methacholine- and substance P-induced secretion in anesthetized rats.
- Investigated the influence of atropine and reserpine pretreatment on these interactions.
Main Results:
- Low doses of clonidine and guanabenz inhibited secretory responses.
- Amphetamine (300 micrograms/kg) antagonized these inhibitory effects without causing salivation itself.
- Amphetamine did not affect atropine-induced blockade, and reserpine pretreatment did not alter amphetamine's effects.
Conclusions:
- Amphetamine's interaction with alpha 2-adrenoreceptor agonists is not due to indirect mechanisms.
- Results suggest a direct interaction between amphetamine and postsynaptic inhibitory alpha 2-adrenoreceptors.