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Brain Imaging

Brain Imaging

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Updated: Feb 22, 2026

An Invasive Method for the Activation of the Mouse Dentate Gyrus by High-frequency Stimulation

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Published on: June 2, 2018

Deep brain stimulation: foundations and future trends.

David J Aum¹, Travis S Tierney²

¹University of South Florida Morsani College of Medicine, 12901 Bruce B Downs Blvd, Tampa, FL 33612.

Frontiers in Bioscience (Landmark Edition)

|September 21, 2017

Summary

This summary is machine-generated.

Deep brain stimulation (DBS) offers a reversible treatment for essential tremor, Parkinson's disease, dystonia, and OCD. It works by inducing neuroplasticity and functional brain changes, providing therapeutic benefits and insights into brain physiology.

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Last Updated: Feb 22, 2026

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Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

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Area of Science:

Neurology
Neurosurgery
Neuroscience

Background:

Deep brain stimulation (DBS) is a key therapy for movement disorders and OCD.
Understanding DBS mechanisms requires knowledge of basal ganglia function and electrical stimulation principles.

Purpose of the Study:

To review the historical development of DBS.
To explain the technical aspects and risks of DBS.
To explore the physiological and neuroplastic changes induced by DBS, particularly in Parkinson's disease.

Main Methods:

Review of historical literature on DBS.
Analysis of pathophysiological models of basal ganglia disorders.
Examination of electrical stimulation principles and DBS system components.
Investigation of functional and structural brain changes associated with chronic stimulation.

Main Results:

DBS induces rapid physiological, slower metabolic, and long-term neuroplastic changes.
Mechanisms in Parkinson's disease include dopamine release and trophic factor expression.
DBS may offer neuroprotective effects.

Conclusions:

DBS is a safe and reversible therapeutic option for neurological conditions.
DBS provides a valuable tool for studying human brain physiology.
Future directions involve technical and clinical improvements for DBS therapy.