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Related Experiment Videos

Redefining Aging in HIV Infection Using Phenotypes.

David M Stoff1, Karl Goodkin2, Dilip Jeste3

  • 1AIDS Research Training-Health Disparities and HIV Aging/Comorbidity Research Programs, Division of AIDS Research, National Institute of Mental Health, 5601 Fishers Lane Room 9E25, MSC 9831, Bethesda, MD, 20892, USA. dstoff@mail.nih.gov.

Current HIV/AIDS Reports
|September 22, 2017
PubMed
Summary
This summary is machine-generated.

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Phenotypes offer a more insightful approach to understanding aging in people with HIV than chronological age. Research should focus on clinical, biological, and intervention targets for comorbid and cognitive aging phenotypes.

Area of Science:

  • Gerontology and Virology
  • Behavioral Science and Neuroscience

Background:

  • Aging and Human Immunodeficiency Virus (HIV) research often uses chronological age, which may not fully capture biological complexities.
  • Phenotypes, defined as behavioral dimensions linked to fundamental mechanisms, offer a potentially more informative alternative for understanding aging processes in the context of HIV.

Purpose of the Study:

  • To critically review the utility of phenotypes as behavioral descriptors in aging/HIV research.
  • To redefine aging within the context of HIV infection using a phenotypic approach.
  • To explore the relationship between aging phenotypes and biological underpinnings for treatment development.

Main Methods:

  • Critical review of existing literature on aging and HIV.
  • Phenotypic redefinition of aging, focusing on behavioral dimensions.
Keywords:
AgingCognitive agingComorbid agingHIVInterventionsPhenotypes

Related Experiment Videos

  • Analysis of phenotypes including comorbid aging, cognitive aging, disability, frailty, accelerated aging, and successful aging.

    • Main Results:

    • Comorbid aging and cognitive aging phenotypes are distinct yet overlapping in HIV.
    • Associative relationships are prevalent in HIV for comorbid and cognitive aging phenotypes.
    • Current HIV behavioral interventions for these aging phenotypes are limited.

    Conclusions:

    • Phenotype-defined aging offers a nuanced perspective beyond chronological age in HIV research.
    • Future research should prioritize clinical and behavioral specification, biological mechanisms, and intervention targets for aging phenotypes in HIV.
    • Identifying specific research questions is crucial for advancing phenotype-defined aging/HIV research.