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Microsponge Embedded Tablets for Sustained Delivery of Nifedipine
Rahul Maheshwari1, Piyoosh Sharma2, Muktika Tekade3
1Pharmaceutical Research Lab, Department of Pharmaceutics, BM College of Pharmaceutical Education and Research, Khandwa Road, Indore 452020, Madhya Pradesh. India.
Pharmaceutical Nanotechnology
|September 22, 2017
Summary
Nifedipine sustained-release tablets were developed using microsponges to overcome its short half-life. The optimized formulation demonstrated prolonged drug release and stability, offering therapeutic advantages.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Materials Science
Background:
- Nifedipine is a cardiovascular drug with a short half-life (2 hours), limiting its therapeutic efficacy.
- Developing sustained-release formulations is crucial for improving patient compliance and treatment outcomes.
Purpose of the Study:
- To develop and optimize nifedipine-loaded sustained-release microsponges.
- To formulate these microsponges into tablets for enhanced clinical application and patient compliance.
Main Methods:
- Microsponges prepared using emulsion solvent diffusion technique with varying nifedipine:polymer ratios (1:1, 1:2, 1:3).
- Optimized microsponges (MF-3) characterized for morphology, flow properties, and drug content.
- Tablets formulated with MF-3 and excipients (MCC, starch); evaluated for in vitro drug release and stability.
Main Results:
- Optimized microsponges (MF-3, 1:3 ratio) showed good powder flow and 80% drug content.
- Tablet formulation TF-33 (48% MF-3) achieved 92.73% drug release over 24 hours, outperforming commercial products.
- Stability studies confirmed good drug retention and consistent release over 90 days at 40°C/75% RH.
Conclusions:
- The nifedipine microsponge tablet delivery system offers superior therapeutic advantages.
- This formulation demonstrates manufacturing feasibility for effective nifedipine delivery.
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