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Rod-Like Virus-Based Multiarm Colloidal Molecules.

Alexis de la Cotte1, Cheng Wu1, Marie Trévisan1

  • 1Centre de Recherche Paul-Pascal, CNRS, and Université de Bordeaux , 115 Avenue Schweitzer, 33600 Pessac, France.

ACS Nano
|September 22, 2017
PubMed
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Researchers created multiarm colloidal molecules using engineered viruses. These stable, virus-based structures have controllable valency and dynamics, demonstrated via fluorescence microscopy.

Area of Science:

  • Biotechnology
  • Materials Science
  • Nanotechnology

Background:

  • Filamentous bacteriophages offer a versatile platform for constructing nanoscale materials.
  • Functionalization strategies are crucial for controlling self-assembly and colloidal properties.

Purpose of the Study:

  • To engineer multiarm colloidal molecules using tip-functionalized filamentous bacteriophages.
  • To investigate the self-assembly dynamics and valency control of virus-based colloidal structures.

Main Methods:

  • Genetic engineering and chemical conjugation to functionalize bacteriophages.
  • Biotinylation protocol for regioselective modification of viral particles.
  • Quantitative modeling to analyze self-assembly and interactions with streptavidin.
  • Conjugation with streptavidin-activated nanoparticles to form multiarm structures.
Keywords:
M13 bacteriophagecolloidal moleculehybridnanorodself-assemblystar polymertunable valency

Related Experiment Videos

  • Fluorescence microscopy to observe real-time dynamics.

    • Main Results:

    • Developed a biotinylation protocol with >90% yield for efficient viral functionalization.
    • Successfully constructed stable virus-based colloidal molecules with tunable valency.
    • Demonstrated precise control over the number of arms (valency) by adjusting molar excess.
    • Validated experimental findings with a quantitative self-assembly model.

    Conclusions:

    • Tip-functionalized bacteriophages enable the creation of controllable, multiarm colloidal molecules.
    • Virus-based colloidal systems offer a robust platform for advanced nanomaterial design.
    • The developed methods provide precise control over structure formation and dynamics.