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Updated: Feb 22, 2026
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Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
Published on: April 22, 2022
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Increased plasma proline concentrations are associated with sarcopenia in the elderly
Kenji Toyoshima1, Marie Nakamura1, Yusuke Adachi2
1Department of Geriatric and Vascular Medicine, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
Plos One
|September 22, 2017
Summary
Plasma amino acid profiles may indicate sarcopenia. Higher proline levels were independently linked to sarcopenia in older adults, suggesting proline
Area of Science:
- Geriatric Medicine
- Metabolomics
- Nutritional Biochemistry
Background:
- Plasma amino acid profiles are linked to diseases like cancer and diabetes.
- The relationship between plasma amino acids and sarcopenia is not well understood.
Purpose of the Study:
- To investigate if plasma amino acid profiles change in individuals with sarcopenia.
- To identify specific amino acid alterations associated with sarcopenia.
Main Methods:
- Cross-sectional analysis of 160 elderly individuals (mean age 77.7 years).
- Comprehensive geriatric assessment including hand grip strength, gait speed, and muscle mass.
- Blood chemistry analysis measuring 18 plasma amino acid concentrations.
Main Results:
- Sarcopenia was diagnosed in 28 participants based on established criteria.
- Univariate analysis showed associations between sarcopenia and higher plasma proline and glutamine, and lower histidine and tryptophan.
- Multivariable analysis identified higher plasma proline concentration as independently associated with sarcopenia.
Conclusions:
- Plasma proline concentration may serve as a biomarker for sarcopenia.
- Proline levels could offer insights into the pathophysiology of sarcopenia.
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