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Related Experiment Video

Updated: Feb 22, 2026

Murine Model of Metastatic Liver Tumors in the Setting of Ischemia Reperfusion Injury
05:59

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Drag reducing polymers decrease hepatic injury and metastases after liver ischemia-reperfusion.

Samer Tohme1, Marina V Kameneva1,2,3, Hamza O Yazdani1

  • 1Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Oncotarget
|September 24, 2017
PubMed
Summary

Drag reducing polymers (DRPs) significantly reduced the metastatic spread and growth of cancer cells in the liver following surgery-induced injury. This study shows DRPs can protect against liver ischemia-reperfusion injury and improve cancer outcomes.

Keywords:
Ischemia reperfusion injurydrag reducing polymersliverliver metastasismetastatic colorectal cancer

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Immunology

Background:

  • Surgery for solid tumors can promote metastasis through sterile inflammation.
  • Liver ischemia-reperfusion (I/R) injury after hepatic resection accelerates metastatic growth.
  • Drag reducing polymers (DRPs) may mitigate inflammation and improve perfusion.

Purpose of the Study:

  • To investigate the potential of DRPs to reduce metastatic tumor cell capture and growth in the liver following I/R injury.
  • To evaluate the protective effects of DRPs against I/R-induced liver damage.

Main Methods:

  • A segmental ischemia model was used in mice livers.
  • Murine colon adenocarcinoma cells (MC38) were injected into the spleen.
  • DRPs (polyethylene oxide) or control were administered intraperitoneally at reperfusion.

Main Results:

  • Liver I/R accelerated the capture and growth of circulating tumor cells and micrometastases.
  • DRP treatment significantly curtailed these metastatic effects.
  • DRPs reduced hepatocellular damage, neutrophil recruitment, platelet deposition, and inflammatory cytokine release.

Conclusions:

  • DRPs effectively attenuated metastatic tumor development and growth in the context of liver I/R injury.
  • DRPs show promise for clinical investigation to improve cancer-specific outcomes after liver surgery.