Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pore Transport and Ion-Pair Transport01:17

Pore Transport and Ion-Pair Transport

1.4K
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
1.4K
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

37
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
37
Mechanism of Filopodia Formation01:39

Mechanism of Filopodia Formation

3.3K
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Statistical physics of the two-dimensional Coulomb liquid with ionic hard-core size.

The Journal of chemical physics·2026
Same author

Unified Theory of Equilibrium Thermodynamics and Ion Association in Aqueous and Nonaqueous Electrolytes with Explicit Hard-Core Size.

Journal of chemical theory and computation·2026
Same author

Self-consistent electrostatic formalism of bulk electrolytes based on the asymmetric treatment of the short- and long-range ion interactions.

Soft matter·2024
Same author

Systematic Incorporation of Ionic Hard-Core Size into the Debye-Hückel Theory via the Cumulant Expansion of the Schwinger-Dyson Equations.

Journal of chemical theory and computation·2024
Same author

Impact of the inner solute structure on the electrostatic mean-field and strong-coupling regimes of macromolecular interactions.

Physical review. E·2023
Same author

Theoretical and computational analysis of the electrophoretic polymer mobility inversion induced by charge correlations.

Physical review. E·2023
Same journal

The influence of chirality on the macroscopic behavior of multiferroic smectic phases.

The Journal of chemical physics·2026
Same journal

Polaron transformed canonically consistent quantum master equation.

The Journal of chemical physics·2026
Same journal

The x-ray absorption spectrum of the propargyl radical C3H3●.

The Journal of chemical physics·2026
Same journal

Transient hydroperoxyalkyl intermediates (•QOOH) in isopentane oxidation. I. Conformer- and isomer-resolved infrared spectra.

The Journal of chemical physics·2026
Same journal

Transient hydroperoxyalkyl intermediates (•QOOH) in isopentane oxidation. II. Isomer-resolved unimolecular dynamics.

The Journal of chemical physics·2026
Same journal

Quantum state-to-state dynamics studies of the C(3P) + OH(X2Π) → CO(a3Π) + H(2S) reaction based on a new HCO(12A″) potential energy surface.

The Journal of chemical physics·2026
See all related articles

Related Experiment Video

Updated: Feb 22, 2026

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
10:43

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

Published on: July 19, 2022

3.0K

Controlling polymer capture and translocation by electrostatic polymer-pore interactions.

Sahin Buyukdagli1, T Ala-Nissila2

  • 1Department of Physics, Bilkent University, Ankara 06800, Turkey.

The Journal of Chemical Physics
|September 24, 2017
PubMed
Summary
This summary is machine-generated.

Understanding polymer translocation through nanopores requires accounting for electrostatic barriers. A specific salt concentration optimizes polymer capture, with translocation time controlled by membrane charge, pore radius, and salt concentration.

More Related Videos

Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions
14:43

Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions

Published on: August 27, 2014

12.1K
High Resolution Physical Characterization of Single Metallic Nanoparticles
09:56

High Resolution Physical Characterization of Single Metallic Nanoparticles

Published on: June 28, 2019

6.2K

Related Experiment Videos

Last Updated: Feb 22, 2026

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
10:43

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes

Published on: July 19, 2022

3.0K
Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions
14:43

Combining Single-molecule Manipulation and Imaging for the Study of Protein-DNA Interactions

Published on: August 27, 2014

12.1K
High Resolution Physical Characterization of Single Metallic Nanoparticles
09:56

High Resolution Physical Characterization of Single Metallic Nanoparticles

Published on: June 28, 2019

6.2K

Area of Science:

  • Nanotechnology
  • Polymer Physics
  • Physical Chemistry

Background:

  • Polymer translocation experiments often involve driving anionic polyelectrolytes, like DNA, through negatively charged nanopores.
  • Modeling polymer capture and translocation necessitates understanding the electrostatic barrier from like-charge polymer-pore interactions.

Purpose of the Study:

  • To characterize the interplay between the electrostatic barrier, electrophoretic drift, and electro-osmotic flow in polymer translocation.
  • To identify conditions that optimize polymer capture probability and control translocation time.

Main Methods:

  • Coupling of mean-field electrohydrodynamic equations with the Smoluchowski formalism.
  • Analysis of distinct ion density regimes and salt screening effects on drift and barrier phenomena.

Main Results:

  • A characteristic salt concentration maximizes the probability of barrier-limited polymer capture.
  • In the barrier-dominated regime, translocation time (τ) increases exponentially with membrane charge and decays exponentially with pore radius and salt concentration.

Conclusions:

  • Altering membrane charge, pore radius, and salt concentration can efficiently control polymer translocation duration.
  • These findings facilitate more accurate measurements of ionic current signals during translocation.