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Updated: Feb 22, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
Foreseeing the future of glomerular disease through slits: miR-NPNT axis
Reiko Inagi1, Yu Ishimoto2, Tzu-Ming Jao1
1Division of CKD Pathophysiology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Abstract:
Podocyte biology is an important key factor for the maintenance of glomerular function and structure. Nephronectin is a podocyte-derived extracellular matrix protein in the glomerular basement membrane. Suppression of nephronectin expression by microRNA-378a-3p significantly induced proteinuria due to loss of integrity of the glomerular filtration barrier in zebrafish and mice, demonstrating the relevance of the microRNA-nephronectin axis in regulation of the podocyte-glomerular basement membrane interaction and integrity of the glomerular filtration barrier.
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