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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Kidney Disease Measures and Left Ventricular Structure and Function: The Atherosclerosis Risk in Communities Study
Kunihiro Matsushita1,2, Lucia Kwak3,2, Yingying Sang3,2
1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD kmatsus5@jhmi.edu.
Journal of the American Heart Association
|September 24, 2017
Summary
Chronic kidney disease (CKD) significantly impacts left ventricular (LV) mass, size, and function. Albuminuria showed stronger associations with LV alterations than estimated glomerular filtration rate (eGFR) in older adults.
Area of Science:
- Cardiology
- Nephrology
- Cardiorenal Medicine
Background:
- Heart failure is a major complication of chronic kidney disease (CKD).
- Limited research comprehensively examines left ventricular (LV) structure and function in relation to key CKD markers: estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR).
- Understanding these relationships is crucial for managing cardiorenal syndrome.
Purpose of the Study:
- To investigate the association between CKD measures (eGFR and ACR) and LV structure and function.
- To compare the impact of eGFR and ACR on echocardiographic parameters of the left ventricle.
- To provide insights into the pathophysiology of cardiorenal syndrome and guide cardiac assessment in CKD patients.
Main Methods:
- Analysis of echocardiogram data from 4175 Atherosclerosis Risk in Communities (ARIC) study participants (aged 66-90 years).
- Quantification of associations between eGFR and ACR with LV mass, size, systolic function, and diastolic function.
- Statistical adjustments for demographic variables and other potential confounders.
Main Results:
- Both eGFR and ACR were significantly associated with most echocardiogram parameters.
- Reduced eGFR was linked to significantly higher LV mass index.
- Albuminuria (ACR) demonstrated significant associations with most LV parameters, including LV mass index and left atrial volume index, with stronger relationships observed compared to eGFR.
Conclusions:
- LV mass is related to both CKD measures (eGFR and ACR).
- LV size and function are robustly associated with albuminuria.
- Findings highlight the importance of assessing cardiac status in CKD patients, particularly those with albuminuria.
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