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Urinary enzyme excretion after donor nephrectomy.

J S Tapson1, A W Hodson, S M Marshall

  • 1Renal Unit, Freeman Hospital, Newcastle upon Tyne, U.K.

Nephron
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Kidney donors showed higher urinary enzyme excretion, indicating increased renal tubular cell metabolism after nephrectomy. However, long-term compensatory hyperfiltration did not appear to damage these kidney cells.

Area of Science:

  • Nephrology
  • Biochemistry

Background:

  • Long-term kidney donor studies often focus on glomerular function and blood pressure.
  • The impact of compensatory hyperfiltration on renal tubular cells post-nephrectomy is understudied.
  • Urinary high-molecular-weight enzyme excretion is a sensitive marker for renal tubular cell damage.

Purpose of the Study:

  • To compare urinary enzyme excretion in kidney donors versus healthy controls.
  • To assess potential renal tubular cell damage in kidney donors due to compensatory hyperfiltration.

Main Methods:

  • Compared urinary excretion of four enzymes (alanine aminopeptidase, alkaline phosphatase, N-acetyl-beta-D-glucosaminidase, lactate dehydrogenase) in 77 kidney donors and 52 controls.
  • Donors had undergone unilateral nephrectomy up to 21 years prior.

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Main Results:

  • Kidney donors exhibited significantly greater urinary excretion of all four enzymes compared to controls (p < 0.001).
  • No correlation was observed between enzyme excretion levels and glomerular filtration rate or time since nephrectomy.

Conclusions:

  • Elevated urinary enzyme activity in kidney donors suggests increased renal tubular cell metabolism, not damage.
  • Compensatory hyperfiltration appears safe for renal tubular cells in the long term (up to 21 years).