Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

In vitro blood compatibility of surface-modified polyurethanes

G M Bernacca1, M J Gulbransen, R Wilkinson

  • 1University Department of Cardiac Surgery, Royal Infirmary, Glasgow, UK.

Biomaterials
|August 28, 1998
PubMed
Summary

Glucose modification significantly reduced platelet activation and complement C3 activation in polyurethanes, making it the best surface for blood compatibility in artificial heart valves.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mathematical representation and nonlinear modelling of the Wheatley mitral valve.

Medical engineering & physics·2025
Same author

Regularization of a Mathematical Model of the Wheatley Heart Valve.

Journal of biomechanical engineering·2022
Same author

A Mathematical Representation of the Wheatley Heart Valve.

Journal of biomechanical engineering·2021
Same author

Percutaneous heart valves; past, present and future.

Perfusion·2014
Same author

Effect of bending rigidity in a dynamic model of a polyurethane prosthetic mitral valve.

Biomechanics and modeling in mechanobiology·2011
Same author

Microvascular preconditioning is not detectable by corrosion casting in the isolated perfused rat heart after 30 minutes of ischaemia.

Scandinavian cardiovascular journal : SCJ·2008

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Cardiovascular Engineering

Background:

  • Polyurethanes are durable materials for artificial heart valves.
  • Assessing blood compatibility is crucial for material development.

Purpose of the Study:

  • Investigate polyurethane blood compatibility with surface modifications.
  • Evaluate platelet activation, complement C3 activation, and factor XII activation.

Main Methods:

  • In vitro testing of two polyurethanes with various surface modifications.
  • Studied platelet (beta-thromboglobulin) release and complement (C3a) activation.
  • Assessed free plasma and surface-bound factor XII activation using human blood or plasma.

Main Results:

Related Experiment Videos

  • Unmodified polyurethanes showed platelet and complement activation.
  • Glucose modification significantly reduced platelet activation.
  • Polyethylene oxide (PEO) and glycosylation reduced C3 activation.
  • Most modifications increased factor XII activation, with exceptions for platelet glycoprotein fragment and glucose.

Conclusions:

  • Glucose-modified polyurethane surfaces demonstrated the best overall blood compatibility.
  • Surface modification is key to improving polyurethane performance in cardiovascular applications.