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Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

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Published on: March 13, 2018

Scalable Spatial-Spectral Multiplexing of Single-Virus Detection Using Multimode Interference Waveguides.

Damla Ozcelik¹, Aadhar Jain¹, Alexandra Stambaugh¹

¹School of Engineering, University of California Santa Cruz, 1156 High Street, Santa Cruz, CA, 95064, USA.

Scientific Reports

|September 24, 2017

Summary

This summary is machine-generated.

This study presents a novel photonic approach for multiplex analysis, enabling simultaneous detection of multiple viruses with single-virus sensitivity. The scalable optofluidic chip offers fast, accurate, and differentiated diagnoses for infectious diseases.

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Last Updated: Feb 22, 2026

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Published on: March 13, 2018

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Multiplex Detection of Bacteria in Complex Clinical and Environmental Samples using Oligonucleotide-coupled Fluorescent Microspheres

Multiplex Detection of Bacteria in Complex Clinical and Environmental Samples using Oligonucleotide-coupled Fluorescent Microspheres

Published on: October 23, 2011

Area of Science:

Optofluidics
Photonics
Biomedical Diagnostics

Background:

Multiplexing is crucial for rapid, accurate, and differentiated diagnoses.
Current diagnostic methods require improvement in speed and accuracy for multiple targets.

Purpose of the Study:

To introduce a novel, scalable photonic approach for multiplex analysis with single virus sensitivity.
To demonstrate a joint spectral and spatial multiplexing strategy for enhanced diagnostic capabilities.

Main Methods:

Developed a solid-core multimode interference (MMI) waveguide on an optofluidic chip.
Implemented joint spectral and spatial multiplexing using wavelength and channel location.
Utilized time-dependent fluorescence signals to encode spectral and spatial information.

Main Results:

Achieved a 6x multiplex assay with single virus sensitivity.
Demonstrated high-fidelity detection and identification of six different viruses from an influenza panel.
Confirmed the scalability of the multimodal multiplexing strategy for numerous targets or samples.

Conclusions:

The photonic approach offers a highly scalable solution for multiplex diagnostic assays.
The technique enables direct detection of fluorescent targets, including nucleic acids and proteins, unbound in flow.
This method holds broad applicability for advanced biomedical diagnostics.