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Updated: Feb 22, 2026

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
Published on: July 31, 2016
Perioperative fluid and hemodynamic management within an enhanced recovery pathway
Michael W Manning1,2, William Jonathan Dunkman2, Timothy E Miller2
1Division of Cardiothroacic Anesthesia, Department of Anesthesiology, Duke University, Durham, North Carolina.
Abstract:
Goal-directed fluid therapy (GDFT) seeks to improve outcomes through individualized optimization of oxygen delivery using IV fluid and vasoactive infusions. Trials of GDFT show clinical benefits over traditional liberal fluid administration, but fail to demonstrate benefits when compared to a restrictive strategy within an optimized enhanced recovery protocol. The ideal monitors, hemodynamic goals, and fluid administration strategy are not well established but may be less important than rational application of thoughtful fluid management strategies.
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