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Three-dimensional image analysis for staging chronic rhinosinusitis.

Sooyoung Lim¹, Michael V Ramirez¹, Jonathan C Garneau¹

¹Pritzker School of Medicine, University of Chicago, Chicago, IL.

International Forum of Allergy & Rhinology

|September 24, 2017

Summary

This summary is machine-generated.

Quantitative sinus inflammation measurement using 3D imaging correlates with patient symptoms and quality of life. This new Chicago-modified Lund-Mackay (Chicago MLM) score shows promise as an imaging biomarker for chronic rhinosinusitis (CRS).

Keywords:

biomarkers paranasal sinus diseases quality of life sinusitis spiral computed tomography

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Area of Science:

Medical Imaging
Otolaryngology
Biomarkers

Background:

Traditional imaging for chronic rhinosinusitis (CRS) fails to quantify partial mucosal inflammation.
This limitation hinders the use of imaging as a reliable biomarker for disease severity.
A novel quantitative approach is needed to better assess sinus inflammation.

Purpose of the Study:

To develop and validate a software-aided, quantitative method for measuring sinus inflammation.
To assess if this quantitative metric correlates with clinical parameters in patients with suspected sinus disease.
To establish a more precise imaging biomarker for CRS.

Main Methods:

Adults with CRS symptoms and computed tomography (CT) scans were recruited.
A semiautomated 3D volumetric image analysis generated a Chicago-modified Lund-Mackay (Chicago MLM) score.
Linear regression analyzed the association between Chicago MLM scores and symptom/quality-of-life scores (TNSS, SNOT-22).

Main Results:

The Chicago MLM score showed significant correlation with patient symptoms (p=0.037) and quality of life (p=0.007).
Inflammation in ethmoid and sphenoid sinuses notably influenced these associations.
The correlations were stronger in patients with more severe disease (LM >6).

Conclusions:

Computer-aided 3D analysis of sinus inflammation provides a quantitative measure correlating with symptoms and quality of life.
Posterior sinuses appear critical, offering potential therapeutic targets.
The Chicago MLM score is a promising imaging biomarker for both clinical practice and research in CRS.