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Related Experiment Videos

Esmolol and left ventricular function in the awake dog.

J R Jacobs1, G W Maier, J S Rankin

  • 1Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710.

Anesthesiology
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

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Anesthesiology·2019

Esmolol, a beta 1-adrenergic antagonist, can cause hypotension by decreasing stroke volume. This study in dogs confirmed esmolol

Area of Science:

  • Cardiovascular Pharmacology
  • Cardiac Physiology
  • Drug Safety

Background:

  • Hypotension is a common adverse effect of esmolol, a beta 1-adrenergic receptor antagonist.
  • This hypotension may stem from decreased stroke volume, independent of heart rate or vascular resistance changes.
  • The preload recruitable stroke work area (PRSWA) model offers a method to assess cardiac contractility.

Purpose of the Study:

  • To evaluate the negative inotropic effects of esmolol using the PRSWA model in awake dogs.
  • To quantify the dose-dependent impact of esmolol on left ventricular function.
  • To determine the reversibility of esmolol's cardiac effects after cessation of infusion.

Main Methods:

  • Nine chronically instrumented awake dogs were studied.

Related Experiment Videos

  • Left ventricular (LV) transmural pressure and minor axis diameter were measured.
  • Vena caval occlusions were performed to assess stroke work across varying preload conditions during esmolol infusions at multiple doses (0–3000 µg/kg/min).

    • Main Results:

    • Esmolol significantly depressed LV peak positive dP/dt, minor axis ejection shortening, stroke work, and PRSWA at doses ≥ 300 µg/kg/min.
    • Heart rate was only elevated at the highest esmolol dose.
    • All measured cardiac function parameters, except dP/dt, recovered within 30 minutes post-infusion.

    Conclusions:

    • Esmolol exhibits dose-dependent negative inotropic effects in conscious dogs, impacting stroke volume.
    • The PRSWA model effectively quantifies esmolol's impact on cardiac contractility.
    • These findings support the understanding of esmolol-induced hypotension and its reversibility.