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Exercise-dependent regulation of the tumour microenvironment
Graeme J Koelwyn1, Daniela F Quail2, Xiang Zhang3
1NYU Langone Medical Center, Marc and Ruti Bell Vascular Biology and Disease Program, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA.
Nature Reviews. Cancer
|September 26, 2017
Summary
Regular exercise may reduce cancer risk and improve outcomes by reprogramming the tumor microenvironment (TME). This study explores how exercise-induced systemic changes influence TME components and cancer hallmarks.
Area of Science:
- Oncology
- Exercise Physiology
- Cancer Biology
Background:
- The tumor microenvironment (TME) is plastic and influenced by systemic factors.
- Lifestyle factors like exercise impact cancer risk and outcomes.
- Molecular mechanisms linking exercise to anti-tumor effects are unclear.
Purpose of the Study:
- To explore how exercise reprograms host-TME interactions.
- To investigate exercise's effects on distant tissue microenvironments.
- To analyze how systemic milieu alterations modulate TME components and cancer hallmarks.
Main Methods:
- Review and synthesis of existing literature on exercise, systemic factors, and TME.
- Speculative analysis of molecular mechanisms.
- Exploration of how exercise influences the 'systemic milieu'.
Main Results:
- Exercise exposure reduces cancer development risk and may improve outcomes.
- Exercise may reprogram distant tissue microenvironments.
- Alterations in the systemic milieu by exercise could influence TME composition.
Conclusions:
- Exercise has potential anti-tumor effects mediated by systemic changes.
- Further research is needed to elucidate the molecular mechanisms.
- Understanding these mechanisms could lead to novel cancer prevention and treatment strategies.
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