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Detrimental haemodynamic effects of cyclizine in heart failure

L B Tan1, S Bryant, R G Murray

  • 1Cardiac Department, John Radcliffe Hospital, Oxford.

Lancet (London, England)
|March 12, 1988
PubMed

Insights

Intravenous cyclizine, an antiemetic, was studied in severe heart failure patients. It increased blood pressure and filling pressures, suggesting it should be avoided in heart failure cases.

Area of Science:

  • Cardiology
  • Pharmacology
  • Critical Care Medicine

Background:

  • Cyclizine is an antiemetic commonly administered with opioids.
  • Its use is noted in patients with left ventricular failure and myocardial infarction.
  • Hemodynamic effects in severe heart failure are not well understood.

Purpose of the Study:

  • To investigate the hemodynamic effects of intravenous cyclizine.
  • To assess its impact on patients with severe heart failure.

Main Methods:

  • Studied 11 patients diagnosed with severe heart failure.
  • Administered intravenous cyclizine and monitored hemodynamic parameters.

Main Results:

  • Cyclizine significantly elevated systemic and pulmonary arterial pressures.
  • It also increased right and left ventricular filling pressures.
  • The drug counteracted the venodilatory effects of diamorphine.

Conclusions:

  • Intravenous cyclizine adversely affects hemodynamics in severe heart failure.
  • Its use in heart failure patients is strongly discouraged.
  • Clinicians should avoid cyclizine in this patient population.

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