Related Experiment Video
Updated: Feb 22, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
15.0K
[Cardiac lymphatic system]
Barbara Garmy-Susini1, Nathalie Pizzinat1, Nicole Villeneuve2
1Institut des maladies métaboliques et cardiovasculaires (I2MC), université de Toulouse, Inserm U1048, université Paul Sabatier, 1, avenue Jean Poulhès, 31432 Toulouse, France.
Medecine Sciences : M/S
|September 26, 2017
Summary
Cardiac lymphatic vessels are crucial for heart health, draining fluid and preventing edema. Dysfunction after myocardial infarction worsens fibrosis, but stimulating lymphangiogenesis may offer new therapeutic strategies.
Area of Science:
- Cardiovascular Science
- Lymphatic Biology
- Regenerative Medicine
Background:
- The lymphatic system maintains fluid balance and immune function.
- Cardiac lymphatics' role in cardiovascular disease is understudied.
- Understanding cardiac lymphatic function is vital for heart health.
Purpose of the Study:
- To review key discoveries in cardiac lymphatic development and function.
- To highlight the role of cardiac lymphatics in myocardial infarction.
- To explore therapeutic potential for cardiac lymphatic dysfunction.
Main Methods:
- Literature review of cardiac lymphatic research.
- Analysis of physiological roles in fluid homeostasis.
- Examination of lymphatic changes post-myocardial infarction.
Main Results:
- Cardiac lymphatics dynamically regulate interstitial fluid drainage.
- Myocardial infarction leads to dysfunctional cardiac lymphatics and edema.
- This dysfunction exacerbates cardiac fibrosis and impaired function.
Conclusions:
- Cardiac lymphatic function is essential for maintaining heart homeostasis.
- Dysfunctional cardiac lymphatics contribute to adverse remodeling after myocardial infarction.
- Targeting cardiac lymphangiogenesis with growth factors like VEGF-C presents a promising therapeutic avenue.
Related Concept Videos
01:16Lymphatic Vessels and Lymph Transport
23.8K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
23.8K
01:28Functions of the Lymphatic and Immune System
7.3K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
7.3K
01:15Development of the Lymphatic System
2.3K
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
2.3K
01:23Detailed Structure and Function of Lymph Nodes
5.2K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
5.2K
01:23Introduction to Lymphatic and Immune System
18.2K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
18.2K
01:20Fluid Connective Tissues: Blood and Lymph
19.5K
Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and...
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and...
19.5K