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Intrinsic capacity evolution during aging in mouse and fish: Longitudinal perspectives from a narrative review
I-Tzu Chen1, Wan-Hsuan Lu2, Fei-Yuan Hsiao3
1IHU HealthAge, Toulouse, France; Center for Healthy Longevity and Aging Sciences National Yang Ming Chiao Tung University, Taipei, Taiwan.
Ageing Research Reviews
|May 20, 2026
Summary
Intrinsic capacity (IC) declines with age across multiple domains in preclinical models. This review details how locomotion, cognition, and sensory functions change longitudinally in mice and fish, aiding aging research.
Area of Science:
- Gerontology and aging research
- Comparative biology and aging models
- Translational preclinical research
Background:
- Intrinsic capacity (IC) is key to healthy aging, encompassing locomotion, cognition, vitality, psychological, and sensory domains.
- Preclinical models with accelerated aging profiles are vital for understanding IC and supporting bidirectional translation in geroscience.
Purpose of the Study:
- To review measurement approaches for each IC domain.
- To describe the longitudinal evolution of IC in mouse and fish models.
Main Methods:
- Narrative literature review of studies in PubMed, Embase, and Web of Science.
- Analysis of 27 mouse model studies and 5 fish model studies.
Main Results:
- Locomotor capacity declines in middle age in mice (earlier in females) and late in life in fish.
- Sensory functions (hearing, vision) decline early (midlife) in mice.
- Cognitive, vitality, and psychological capacities show age-related changes in later life across models.
Conclusions:
- Longitudinal IC changes vary between species and domains.
- Findings provide a foundation for mechanistic studies on aging.
- Enhances the translational value of preclinical models for IC research.
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