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Voluptuary Habits and Risk of Frontotemporal Dementia: A Case Control Retrospective Study.
Lucio Tremolizzo1,2, Elisa Bianchi3, Emanuela Susani1
1Neurology Unit, San Gerardo Hospital, Monza, Italy.
Journal of Alzheimer'S Disease : JAD
|September 27, 2017
Summary
This study found that alcohol consumption may reduce the risk of frontotemporal dementia (FTD). Coffee and tobacco showed no association with FTD risk in this case-control study.
Area of Science:
- Neuroscience
- Epidemiology
- Public Health
Background:
- Frontotemporal dementia (FTD) is a progressive neurodegenerative disorder.
- Understanding lifestyle factors associated with FTD risk is crucial for prevention strategies.
Purpose of the Study:
- To investigate the association between alcohol, coffee, and tobacco consumption and the risk of developing frontotemporal dementia (FTD).
Main Methods:
- A multicenter retrospective case-control study was conducted.
- 151 FTD outpatients were compared with 151 matched controls.
- Consumption of alcohol, coffee, and tobacco was assessed for each participant.
Main Results:
- No significant association was found between smoking or coffee intake and FTD risk.
- Alcohol consumption was associated with a reduced risk of FTD (adjusted OR 0.30).
- A significant risk reduction was observed in current alcohol consumers (adjusted OR 0.22).
- FTD risk inversely correlated with the duration of alcohol exposure (adjusted OR 0.88 per 5 years).
Conclusions:
- Alcohol consumption, particularly among current consumers and with longer duration of use, may be associated with a decreased risk of frontotemporal dementia.
- Coffee and tobacco consumption do not appear to be associated with FTD risk.
- Limitations include retrospective data collection and unknown quantities of alcohol consumed.
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