Elevated DNA Damage, Oxidative Stress, and Impaired Response Defense System Inflicted in Patients With Myocardial...

Area of Science:

• Cardiology
• Biochemistry
• Oxidative Stress Research

Background:

• Myocardial infarction (MI) is associated with excessive reactive oxygen species (ROS) production, overwhelming the body's antioxidant defenses and leading to oxidative stress in heart tissue.
• This imbalance results in damage to myocardial tissue due to uncontrolled oxidative burden.

Purpose of the Study:

• To investigate the redox status in patients with MI by assessing antioxidant potential and oxidative stress biomarkers.
• To compare these markers in MI patients based on Global Registry of Acute Coronary Events (GRACE) score, risk factors, and age against healthy controls.

Main Methods:

• Evaluated antioxidant potential, oxidative stress biomarkers (e.g., malondialdehyde, 8-hydroxy-2-deoxyguanosine), lipid profiles, and red blood cell (RBC) membrane damage in 125 MI patients and healthy individuals.
• Stratified MI patients by GRACE score (≤100 vs. >100), presence of risk factors, and age (≤45 vs. >45 years).

Main Results:

• MI patients showed elevated oxidative stress markers (malondialdehyde, 8-hydroxy-2-deoxyguanosine), increased lipid indices, higher ROS levels, and significant RBC membrane damage compared to controls.
• Reduced erythrocyte antioxidant enzyme activity, lower plasma antioxidant concentrations, and decreased total antioxidant capacity were observed in MI patients.
• Oxidative stress was significantly more pronounced in MI patients with GRACE scores >100, presence of risk factors, and age >45 years.

Conclusions:

• Patients with MI exhibit substantial oxidative damage and impaired antioxidant capacity.
• These oxidative changes are strongly correlated with higher GRACE risk scores, the presence of cardiovascular risk factors, and older age in MI patients.