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Relationship Between Plasma Pentraxin 3 Concentration and Platelet Indices in Patients With Stable Coronary Artery

Ilona Korzonek-Szlacheta1, Aleksander Danikiewicz1, Janusz Szkodziński2

  • 11 Department of Nutrition-Related Disease Prevention, Faculty of Public Health, Medical University of Silesia, Bytom, Poland.

Angiology
|September 27, 2017
PubMed

Insights

Pentraxin 3 (PTX3) is linked to larger platelet size in coronary artery disease patients. Higher PTX3 levels correlate strongly with increased mean platelet volume (MPV) and platelet distribution width (PDW).

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Inflammation Research

Background:

  • Pentraxin 3 (PTX3) is an acute-phase protein involved in inflammation.
  • Limited research exists on the relationship between PTX3 and platelet activation markers.

Purpose of the Study:

  • To investigate the association between plasma PTX3 levels and various platelet indices in patients with stable coronary artery disease (CAD).

Main Methods:

  • Forty-nine stable CAD patients were categorized into two groups based on median PTX3 levels.
  • Platelet indices including mean platelet volume (MPV), platelet distribution width (PDW), and others were analyzed.
  • Statistical correlations between PTX3 and platelet indices were assessed.

Main Results:

  • Patients with higher PTX3 concentrations exhibited significantly elevated MPV and PDW.
  • Plasma PTX3 showed a strong positive correlation with MPV (r = .75) and PDW (r = .80).
  • Thromboinflammatory biomarkers like platelet-to-lymphocyte ratio (PLR) and MPV-to-lymphocyte ratio (MPVLR) were also elevated in the high PTX3 group.

Conclusions:

  • Plasma PTX3 levels are associated with larger platelet size, as indicated by increased MPV and PDW.
  • PTX3 may play a role in platelet activation and thromboinflammation in CAD patients.

Keywords:
coronary artery diseasemean platelet volumemean platelet volume to lymphocyte ratiopentraxin 3platelet distribution widthplatelet indicesplatelet to lymphocyte ratio

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