Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

779
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
779

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain network pathophysiology in dystonia.

Dystonia (Lausanne, Switzerland)·2026
Same author

Parkinson's disease: Individual placebo responses are predicted by baseline expression of a striato-limbic network.

Research square·2026
Same author

Non-invasive identification of brain signatures of acute liver injury.

Theranostics·2026
Same author

Utility of [<sup>18</sup>F]PI-2620 as Universal Biomarker for the Amyloid/Tau/Neurodegeneration Classification of Alzheimer Disease: An Exploratory Study with Dual-Phase PET Imaging.

AJNR. American journal of neuroradiology·2026
Same author

Beyond Parkinsonism: 18 F-FDOPA Brain PET/MRI for Detection of High-grade Glioma.

Clinical nuclear medicine·2026
Same author

Metabolic brain networks in dementia with Lewy bodies: from prodromal to manifest disease stages.

Journal of neurology, neurosurgery, and psychiatry·2025

Related Experiment Video

Updated: Feb 22, 2026

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI&#8212;Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

12.7K

Functional imaging in Huntington disease.

Martin Niethammer1, David Eidelberg2

  • 1Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, United States; Department of Neurology, North Shore University Hospital, Manhasset, NY, United States.

Handbook of Clinical Neurology
|September 27, 2017
PubMed
Summary

Functional imaging techniques reveal neurochemical and functional changes in neurodegenerative diseases like Huntington disease (HD). These methods aid in identifying biomarkers for tracking disease progression, especially in presymptomatic stages.

Keywords:
Huntington diseasedisease progressionfunctional MRIradiotracer imagingresting state network

More Related Videos

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

6.7K
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

981

Related Experiment Videos

Last Updated: Feb 22, 2026

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI&#8212;Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

12.7K
Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice
08:27

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

Published on: March 11, 2020

6.7K
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

981

Area of Science:

  • Neuroscience
  • Radiology
  • Medical Imaging

Background:

  • Functional imaging offers insights into neurochemical and functional changes in neurodegenerative diseases, complementing structural imaging.
  • Huntington disease (HD) diagnosis is certain via genetic testing, shifting research focus to underlying pathophysiology and progression biomarkers.
  • Existing research has moved beyond dopaminergic deficits and striatal cell loss in HD, revealing widespread network alterations.

Purpose of the Study:

  • To review current literature on radiotracer and functional magnetic resonance imaging (fMRI) in Huntington disease (HD).
  • To highlight the role of functional imaging in understanding HD pathophysiology and identifying biomarkers.
  • To discuss how imaging elucidates neurochemical and functional changes in HD, particularly during the presymptomatic stage.

Main Methods:

  • Review of current literature on radiotracer imaging in HD.
  • Review of current literature on functional magnetic resonance imaging (fMRI) in HD.
  • Synthesis of findings related to neurochemical and functional changes in HD.

Main Results:

  • Functional imaging reveals alterations in widespread networks associated with motor and cognitive symptoms in HD.
  • Imaging methods have expanded understanding of HD beyond traditional markers like dopaminergic deficits.
  • Potential biomarkers for monitoring HD progression, including in the presymptomatic stage, have been identified.

Conclusions:

  • Functional imaging is crucial for understanding Huntington disease (HD) pathophysiology and progression.
  • Radiotracer and fMRI techniques provide valuable insights into neurochemical and network changes in HD.
  • These imaging modalities are essential for identifying biomarkers to monitor HD, especially in presymptomatic individuals.