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Development and validation of the Frontal Fibrosing Alopecia Severity Score
David Saceda-Corralo1, Óscar Muñoz Moreno-Arrones2, Pablo Fonda-Pascual2
1Dermatology Department, Ramon y Cajal University Hospital, Madrid, Spain; Grupo de Dermatología Pedro Jaen, Madrid, Spain; Department of Medicine and Medical Specialties, University of Alcalá, Alcalá de Henares-Madrid, Madrid, Spain.
Background:
Frontal fibrosing alopecia (FFA) is a scarring alopecia characterized by recession of the frontotemporal hairline and loss of the eyebrows.
Objective:
To design and validate a scoring system to assess the severity of FFA.
Methods:
The Frontal Fibrosing Alopecia Severity Score (FFASS) was developed; criterion validity was assessed by the Investigator's Global Assessment, and construct validity was evaluated by the convergence of other measures of severity (the Patient's Global Assessment], the rest of the clinical features, the Lichen Planopilaris Activity Index, and quality of life measures (Dermatology Life Quality Index and Hospital Anxiety Depression Scale). Intraobserver and interobserver reliability were determined.
Results:
In total, 103 female patients were included. The FFASS showed significant correlation to the Patient's Global Assessment, occipital involvement, and the Lichen Planopilaris Activity Index. Intraobserver reliability was completed for 31 subjects and showed good correlation (intraclass correlation coefficient, 0.86; 95% confidence interval, 0.7-0.95; P < .001). Interobserver reliability showed excellent correlation (intraclass correlation coefficient, 0.97; 95% confidence interval, 0.95-0.99; P < .001).
Limitations:
The study was performed at a single institution, and only female patients were assessed.
Conclusions:
The FFASS is a statistically validated scale and a reliable measure of FFA severity, and it can be used in clinical practice and future research studies as an assessment tool.
