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A Simple Blood Test, Such as Complete Blood Count, Can Predict Calcification Grade of Abdominal Aortic Aneurysm

Marika Vezzoli1, Stefano Bonardelli2,3, Michele Peroni2,3

  • 1Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy.

International Journal of Vascular Medicine
|September 27, 2017
PubMed

Insights

Classical risk factors do not predict abdominal aortic aneurysm (AAA) calcification. However, mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) show strong associations with AAA calcification progression.

Area of Science:

  • Cardiovascular Research
  • Medical Diagnostics
  • Atherosclerosis Research

Background:

  • Abdominal aortic aneurysm (AAA) pathogenesis is complex, with calcification linked to increased complications.
  • Identifying factors influencing AAA calcification progression is crucial for patient management.

Purpose of the Study:

  • To investigate if classical AAA risk factors and cell blood count parameters can identify calcification progression.
  • To explore potential biomarkers for monitoring AAA calcification.

Main Methods:

  • Collected risk factor data from patients with AAA.
  • Performed cell blood counts on AAA patients.
  • Assessed aorta calcification using CT angiography.

Main Results:

  • No association found between classical AAA risk factors and calcification grade.
  • Strong association identified between mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) with calcification grade.
  • Other analyzed cell blood count parameters showed no association with calcification.

Conclusions:

  • MCV and MCH show potential as biomarkers for AAA calcification progression.
  • These biomarkers could aid in discriminating patients needing rapid imaging and prompt treatment.
  • Biomarkers may help avoid unnecessary imaging for patients not requiring immediate intervention.
Abstract

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