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Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab
Kristina L Bajema1, Paul D Simonson2,3, Alex L Greninger3
1Division of Allergy and Infectious Diseases, Department of Medicine.
Abstract:
We describe a case of fatal acute liver failure due to echovirus 9 in the setting of persistent B-cell depletion and hypogammaglobulinemia 3 years after rituximab therapy. Metagenomic next-generation sequencing further specified the etiologic agent. Early recognition may provide an opportunity for interventions including intravenous immunoglobulin and liver transplantation.
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