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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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Post-Infectious Irritable Bowel Syndrome.

Yeong Yeh Lee1, Chandramouli Annamalai2, Satish S C Rao3

  • 1School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Current Gastroenterology Reports
|September 27, 2017
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Summary
This summary is machine-generated.

Post-infectious irritable bowel syndrome (PI-IBS) involves gut inflammation and dysfunction after gastroenteritis. Management focuses on symptom relief and addressing underlying pathophysiology for irritable bowel syndrome with diarrhea (IBS-D).

Keywords:
DiarrheaGastroenteritisInflammationIrritable bowel syndromePathophysiology

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Area of Science:

  • Gastroenterology
  • Immunology
  • Microbiology

Background:

  • Post-infectious irritable bowel syndrome (PI-IBS) presents with persistent abdominal pain and diarrhea after infectious gastroenteritis.
  • PI-IBS serves as a valuable model for understanding the broader mechanisms of IBS with diarrhea (IBS-D).

Purpose of the Study:

  • To provide an updated review of the pathophysiology, clinical manifestations, and management strategies for PI-IBS.
  • To elucidate the mechanisms contributing to IBS-D using PI-IBS as a model.

Main Methods:

  • Literature review of current research on PI-IBS.
  • Analysis of the interplay between immune responses, gut inflammation, brain-gut interactions, and microbiota in PI-IBS.

Main Results:

  • Key features of PI-IBS include disordered immune reactions, cytokine release, gut inflammation, and dysfunction.
  • Risk factors such as the infecting agent and host genetics influence clinical severity, with generally good prognosis despite potential long-term symptoms.

Conclusions:

  • Management involves symptomatic relief using antidiarrheals, antispasmodics, 5HT3 antagonists, mesalamine, probiotics, and low-dose antidepressants.
  • Combination therapies targeting pathophysiology may benefit difficult cases, highlighting shared mechanisms and treatments between PI-IBS and IBS-D.