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Hormonal and bone parameters in pubertal girls.

V Cirmanova1, I Zofkova, P Kasalicky

  • 1Institute of Endocrinology, Prague, Czech Republic. vcirmanova@endo.cz.

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Healthy peripubertal girls show positive associations between bone mass and serum leptin. Lean mass also correlates with insulin-like growth factor 1 (IGF-1) and muscle force, highlighting key factors for bone health.

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Area of Science:

  • Pediatric Endocrinology
  • Bone Biology
  • Metabolic Health

Background:

  • Bone mineral content (BMC) and bone density (BMD) are critical for skeletal health.
  • Hormonal and metabolic factors influence bone development during peripuberty.
  • Understanding these relationships is key for optimizing adolescent bone accrual.

Purpose of the Study:

  • To investigate associations between body composition, muscle strength, and hormonal/metabolic markers in peripubertal girls.
  • To identify key factors influencing bone mass and density during this critical developmental stage.

Main Methods:

  • Dual-energy X-ray absorptiometry (DXA) for body composition (BMC, BMD L1-L4, lean mass, fat mass).
  • Dynamometry for muscle force assessment.
  • Quantification of serum/urine hormones (e.g., estradiol, IGF-1, leptin, vitamin D, PTH) and metabolites (melatonin, serotonin).
  • Statistical analysis using partial correlations adjusted for height, Tanner stage, and physical activity.

Main Results:

  • Positive correlations were found between BMC/BMD L1-L4 (Z-score) and lean mass or fat mass.
  • BMC/BMD L1-L4 (Z-score) showed a positive relationship with serum leptin.
  • Lean mass was positively associated with IGF-1, leptin levels, and muscle force after adjustments.

Conclusions:

  • Serum leptin is positively associated with bone mass in peripubertal girls.
  • Lean mass, IGF-1, and muscle force are interconnected, suggesting a coordinated influence on skeletal development.
  • These findings highlight the importance of body composition and hormonal milieu for bone health during adolescence.