Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.5K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.5K
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

850
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
850
Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

835
Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
835
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.1K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.1K
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

670
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
670
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

473
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
473

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of artificial intelligence in predicting COPD exacerbations using multimodal data: a systematic review.

ERJ open research·2026
Same author

Contemporary Transcatheter Approaches to Mitral Regurgitation.

Reviews in cardiovascular medicine·2026
Same author

Arrhythmogenic Cardiomyopathy Diagnosed Late in a Master Recreational Endurance Athlete.

JACC. Case reports·2026
Same author

Decoding the Heart Through Computed Tomography: Early Cardiomyopathy Detection Using Ensemble-Based Segmentation and Radiomics.

Journal of imaging·2026
Same author

Eligibility for biological treatments in COPD patients experiencing a severe COPD exacerbation.

Respiratory medicine·2026
Same author

Long-term immune and epigenetic dysregulation following COVID-19.

Clinical immunology (Orlando, Fla.)·2025

Related Experiment Video

Updated: Feb 22, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
07:24

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

24.7K

Statins and left ventricular function.

Agamemnon Bakakos1, Evangelos Oikonomou1, Georgia Vogiatzi1

  • 11st Department of Cardiology, 'Hippokration' Hospital, University of Athens Medical School, Athens. Greece.

Current Pharmaceutical Design
|September 28, 2017
PubMed
Summary
This summary is machine-generated.

Statins may improve heart function in heart failure patients, particularly those with preserved ejection fraction or ischemic heart disease. However, current evidence does not confirm a mortality benefit for statins in heart failure.

Keywords:
Heart failureLeft ventricle remodelingLeft Ventricle Ejection FractionPleiotropic effectsStatinsdyslipidemia

More Related Videos

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.7K
Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

5.1K

Related Experiment Videos

Last Updated: Feb 22, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
07:24

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

24.7K
Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.7K
Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

5.1K

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Statins are widely used for coronary event prevention and treating atherosclerotic disease.
  • The role of statins in heart failure management remains controversial.

Purpose of the Study:

  • To evaluate the potential benefits of statins' pleiotropic effects in heart failure.
  • Investigate impacts on endothelium, inflammation, cardiac remodeling, and arrhythmia.

Main Methods:

  • Literature search of English-language studies.
  • Keywords: heart failure, statins, HMG-CoA reductase inhibitors.

Main Results:

  • Studies explored statin use across heart failure subtypes based on ejection fraction.
  • Patients with ischemic heart disease and preserved ejection fraction showed better outcomes.
  • Overall mortality benefit in heart failure was not demonstrated in randomized trials.

Conclusions:

  • Statins may positively influence left ventricular systolic and diastolic performance in heart failure.
  • Evidence is insufficient to establish a mortality benefit for statins in heart failure patients.