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β-receptor blockers significantly impact the cardiovascular system by counteracting catecholamine-induced sympathetic responses. These medications decrease heart rate, contractility, and cardiac output, potentially leading to cardiac depression, life-threatening bradycardia, and death. Therapeutically, β-blockers function as mild antihypertensives and are utilized in treating angina pectoris and cardiac arrhythmias. However, nonselective β-blockers inhibit β2-receptors in...
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β2-Adrenoceptor Function in Asthma.

Yassine Amrani1, Peter Bradding1

  • 1University of Leicester, Leicester, United Kingdom.

Advances in Immunology
|September 28, 2017
PubMed
Summary
This summary is machine-generated.

Beta2-adrenoceptor agonists are crucial for asthma treatment but can cause adverse effects. This review explores factors impairing their function, like inflammation and viruses, potentially leading to poor asthma control.

Keywords:
Asthma therapiesBronchodilationCell signalingChronic lung diseasesInflammationMast cellsReceptor desensitization

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Area of Science:

  • Pulmonology
  • Pharmacology
  • Immunology

Background:

  • Beta2-adrenoceptor agonists are standard asthma treatments, often combined with corticosteroids.
  • Concerns exist regarding their safety, including poor asthma control, severe exacerbations, and mortality.

Purpose of the Study:

  • To review experimental evidence on factors blunting beta2-adrenoceptor agonist efficacy in asthma.
  • To explore mechanisms underlying beta2-adrenoceptor dysfunction in airway smooth muscle.

Main Methods:

  • Review of experimental studies investigating factors affecting beta2-adrenoceptor function.
  • Analysis of mechanisms such as receptor uncoupling and desensitization.

Main Results:

  • Inflammatory cytokines, growth factors, viruses, allergens, and atopic asthmatic serum can impair beta2-adrenoceptor function.
  • Mast cells play a role in impairing beta2-adrenoceptor function.
  • Receptor uncoupling and desensitization are key inhibitory pathways.

Conclusions:

  • Multiple factors contribute to beta2-adrenoceptor dysfunction in asthma.
  • Targeting pathways causing beta2-adrenoceptor dysfunction may improve asthma therapy efficacy.