Related Experiment Video
Updated: Feb 22, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Does Acute Otitis Media in the First Month of Life Increase the Risk for Recurrent Otitis?
Orli Megged1, Suzan Abdulgany1, Maskit Bar-Meir1
11 Shaare-Zedek Medical Center (affiliated with Hebrew University-Hadassah School of Medicine), Jerusalem, Israel.
Insights
Infants with acute otitis media (AOM) in their first month are four times more likely to develop recurrent AOM (rAOM) later. This early AOM is a significant predictor of future ear infections in children.
Area of Science:
- Pediatrics
- Otolaryngology
- Infectious Diseases
Background:
- Acute otitis media (AOM) is a prevalent childhood ailment.
- Identifying early predictors for recurrent AOM (rAOM) is crucial for effective management.
Purpose of the Study:
- To determine if AOM in the first month of life predicts rAOM in early childhood.
- To assess the independent predictive value of neonatal AOM for subsequent rAOM.
Main Methods:
- Retrospective review of medical records for neonates diagnosed with AOM and bacterial pathogen isolation.
- Inclusion of a control group of neonates admitted for fever workup without AOM.
- Parental phone interviews to collect data on rAOM and potential risk factors.
Main Results:
- Eighty-four neonates with AOM were identified; 30% experienced rAOM.
- The control group showed a 10% rate of rAOM.
- Neonatal AOM was associated with a fourfold increased odds of rAOM (OR=4, P=.008).
Conclusions:
- AOM during the neonatal period is a significant risk factor for developing recurrent AOM in infancy.
- This association remains significant regardless of other common risk factors like smoke exposure or daycare attendance.
Abstract:
Acute otitis media (AOM) is a common childhood illness. The aim of this study was to assess whether AOM in the first month of life predicts recurrent AOM (rAOM) in early childhood. The medical records of all neonates with AOM and isolation of bacterial pathogen from middle-ear fluid during 2005-2010 were reviewed. Neonates without AOM admitted during the same period for neonatal fever workup were included as controls. Information regarding rAOM and possible risk factors were collected through a phone interview with the parents. A total of 84 neonates with AOM were enrolled; 25 (30%) had rAOM compared with 8/79 (10%) in the control group. Neonatal AOM increases 4-fold the odds of rAOM later in childhood (odds ratio = 4; 95% CI = 1.44-11.42; P = .008), independent of smoke exposure, numbers of siblings, AOM in siblings, breastfeeding, day care attendance, or use of pacifier. Neonatal AOM is a significant risk factor for rAOM during infancy.
More Related Videos
Related Concept Videos
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.
Tonsillitis II: Management
Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

