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Composite Biomaterials Based on Sol-Gel Mesoporous Silicate Glasses: A Review
Francesco Baino1, Sonia Fiorilli2, Chiara Vitale-Brovarone3
1Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, Torino 10129, Italy. francesco.baino@polito.it.
Bioengineering (Basel, Switzerland)
|September 28, 2017
Summary
Mesoporous bioactive glasses, synthesized via sol-gel routes, offer superior bone regeneration and drug delivery capabilities for regenerative medicine. These versatile materials form composite systems and coatings with hierarchical structures for advanced therapeutic applications.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Materials Chemistry
Background:
- Bioactive glasses bond to bone and stimulate tissue growth, making them valuable for regenerative medicine.
- Mesoporous glasses, synthesized via sol-gel routes, represent a novel class of biomaterials.
- These glasses offer enhanced bone regenerative potential compared to traditional melt-derived glasses.
Purpose of the Study:
- To review composite systems and coatings based on mesoporous glasses.
- To highlight the potential of mesoporous glasses in drug delivery and targeted therapy.
- To discuss future challenges and opportunities in the field.
Main Methods:
- Sol-gel synthesis of mesoporous glasses.
- Incorporation of drugs and biomolecules into mesoporous glasses.
- Fabrication of composite systems (microspheres, scaffolds, injectable matrices) and surface coatings.
Main Results:
- Mesoporous glasses exhibit superior bone regenerative potential.
- They can be processed into various forms, including particles, composites, and coatings.
- Hierarchical structures with multiscale porosity can be achieved.
Conclusions:
- Mesoporous glasses are versatile biomaterials for regenerative medicine and targeted therapy.
- Composite systems and coatings offer advanced therapeutic solutions.
- Inorganic-organic hybrid sol-gel biomaterials hold significant future potential.
