Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Flow Cytometry01:23

Flow Cytometry

16.6K
The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
In...
16.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Review on isotachophoresis in trace biochemical sample analysis: state of art and future prospects.

Journal of chromatography. A·2026
Same author

Bridging the gap: enhancing patient and public involvement in dermatology PRO research.

Journal of patient-reported outcomes·2026
Same author

Scalable control techniques for automated configuration of programmable photonic circuits.

Optics letters·2026
Same author

Sequential monitoring and control of a silicon photonic coherent beam adder and analyzer.

Scientific reports·2026
Same author

Design and Implementation of an Eyewear-Integrated Infrared Eye-Tracking System.

Sensors (Basel, Switzerland)·2026
Same author

Antigen flexibility supports the avidity of hemagglutinin-specific antibodies at low antigen densities.

PLoS pathogens·2026

Related Experiment Video

Updated: Feb 22, 2026

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

9.9K

Miniaturized Impedance Flow Cytometer: Design Rules and Integrated Readout.

Marco Carminati, Giorgio Ferrari, Michael D Vahey

    IEEE Transactions on Biomedical Circuits and Systems
    |September 28, 2017
    PubMed
    Summary

    A compact, credit-card-sized impedance cell counter achieves high throughput and single-cell detection. This label-free electrical readout system is ideal for point-of-care diagnostics.

    More Related Videos

    Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM
    07:19

    Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM

    Published on: June 28, 2017

    10.8K
    Wide-field Fluorescent Microscopy and Fluorescent Imaging Flow Cytometry on a Cell-phone
    06:42

    Wide-field Fluorescent Microscopy and Fluorescent Imaging Flow Cytometry on a Cell-phone

    Published on: April 11, 2013

    24.2K

    Related Experiment Videos

    Last Updated: Feb 22, 2026

    Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
    11:54

    Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

    Published on: March 13, 2017

    9.9K
    Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM
    07:19

    Microfluidic Imaging Flow Cytometry by Asymmetric-detection Time-stretch Optical Microscopy ATOM

    Published on: June 28, 2017

    10.8K
    Wide-field Fluorescent Microscopy and Fluorescent Imaging Flow Cytometry on a Cell-phone
    06:42

    Wide-field Fluorescent Microscopy and Fluorescent Imaging Flow Cytometry on a Cell-phone

    Published on: April 11, 2013

    24.2K

    Area of Science:

    • Biomedical Engineering
    • Electrical Engineering
    • Microfluidics

    Background:

    • Traditional cell counting methods often require bulky equipment and fluorescent labeling.
    • There is a need for portable, label-free cell analysis systems for point-of-care applications.

    Purpose of the Study:

    • To develop a compact, high-throughput, dual-channel impedance cell counter.
    • To integrate this counter with a dielectrophoretic cell-sorting microfluidic device for label-free electrical readout.
    • To provide design guidelines for planar sensing microelectrodes in thin channels.

    Main Methods:

    • A credit-card-sized module integrating a CMOS ASIC with a lock-in impedance demodulator, an oversampling 20-bit Sigma-Delta Analog-to-Digital Converter (ADC), and field-programmable gate array (FPGA) for real-time peak detection.
    • Coupling the impedance counter with a dielectrophoretic cell-sorting microfluidic device.
    • Utilizing simulations and experiments to analyze the role of microelectrode dimensions and their effect on thin channel spectra.

    Main Results:

    • Achieved a throughput of 2000 cells/second and detection of single yeast cells (5 μm) with a 20 dB signal-to-noise ratio.
    • Demonstrated a compact, label-free electrical readout system suitable for point-of-care diagnostics, eliminating the need for fluorescence microscopy.
    • Derived design guidelines for planar sensing microelectrodes based on experimental and simulation data.

    Conclusions:

    • The developed dual-channel impedance cell counter offers a compact and efficient solution for cell analysis.
    • The integration with microfluidics provides a label-free, point-of-care diagnostic tool.
    • The study offers valuable design insights for microelectrode configurations in microfluidic impedance sensing.