Related Experiment Video
Updated: Feb 22, 2026
09:36
Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
3.2K
Does inhalation injury predict mortality in burns patients or require redefinition?
Youngmin Kim1, Dohern Kym1, Jun Hur1
1Department of Surgery and Critical Care, Burn Center, Hangang Sacred Heart Hospital, Hallym University Medical Center, Seoul, Korea.
Plos One
|September 28, 2017
Summary
Inhalation injury complicates burn patient outcomes. Age, burn size, and mechanical ventilation predict mortality, while initial diagnostic signs do not reliably predict outcomes.
Area of Science:
- Trauma Surgery
- Critical Care Medicine
- Burn Management
Background:
- Inhalation injury is a critical factor influencing mortality in burn patients.
- Diagnosing inhalation injury is challenging due to varied presentations and difficulty in assessing severity.
Purpose of the Study:
- To identify clinical features of inhalation injury impacting mortality.
- To find predictors for precise outcome assessment in burn patients with inhalation injury.
Main Methods:
- Retrospective observational study of 676 adult burn patients (2012-2015).
- Analysis of prognostic factors: age, % total body surface area (%TBSA) burned, inhalation injury.
- Evaluation of inhalation injury-associated factors: carboxyhemoglobin, PaO2/FiO2 (PF) ratio.
- Application of univariate and multivariate logistic regression.
Main Results:
- Age, %TBSA burned, and mechanical ventilation were significant predictors of mortality (p<0.001).
- Inhalation injury presence, PF ratio, and carboxyhemoglobin were not significant in multivariate analysis.
- Univariate analysis showed inhalation severity groups and PF ratio <100 as significant predictors.
Conclusions:
- Clinical history and physical findings are insufficient for diagnosing inhalation injury or predicting mortality.
- Mechanical ventilation is a significant risk factor for mortality in burn patients with inhalation injury.
More Related Videos
04:56In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells
Published on: October 23, 2018
7.1K
06:22Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
3.9K
Related Concept Videos
01:22Burn Injuries
4.8K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
4.8K
01:21Acute Respiratory Failure-II
1.2K
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.2K
01:23Acute Respiratory Failure-IV
606
Respiratory failure can manifest suddenly or gradually, characterized by a rapid decline in PaO2 and a rapid rise in PaCO2. This situation indicates a severe respiratory problem that may quickly become a life-threatening emergency. One of the early signs of hypoxemic Acute Respiratory Failure (ARF) is a change in mental status due to the brain's sensitivity to oxygen levels and changes in acid-base balance. Symptoms such as restlessness, confusion, and agitation suggest inadequate oxygen...
606
01:30Acute Respiratory Failure-III
972
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
972
01:20Inhalational Anesthetics: Overview
1.3K
Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
1.3K
01:29Acute Respiratory Failure-V
540
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Ensure that patients are monitored continuously for their response to therapy, including changes in...
540