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Comparative Performance of SLECRISK and PREVENT for Cardiovascular Risk Prediction in Systemic Lupus Erythematosus
Youngmin Kim1, Hongshu Guan2, May Y Choi3
1Y. Kim, MD, Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
The Journal of Rheumatology
|August 1, 2026
Summary
The SLECRISK model shows higher sensitivity in identifying Systemic Lupus Erythematosus (SLE) patients at risk for cardiovascular events compared to the PREVENT model. This disease-specific tool aids in better cardiovascular risk stratification for SLE patients.
Area of Science:
- Rheumatology
- Cardiology
- Epidemiology
Background:
- Systemic Lupus Erythematosus (SLE) patients face increased cardiovascular disease (CVD) risk.
- Existing CVD risk models may not fully capture risk in SLE due to unique risk factor profiles.
Purpose of the Study:
- To compare the predictive performance of SLECRISK, an SLE-specific CVD risk model, against the PREVENT model in an SLE cohort.
- To evaluate the models' ability to identify patients who develop major adverse cardiovascular events (MACE).
Main Methods:
- Adult SLE patients meeting ACR/EULAR criteria were included.
- 10-year risk for myocardial infarction, stroke, or cardiac death was predicted using SLECRISK and PREVENT.
- Model discrimination and performance were assessed and compared.
Main Results:
- Both SLECRISK and PREVENT showed similar discrimination (AUC 0.74 vs. 0.76).
- SLECRISK demonstrated significantly higher sensitivity (0.74 vs. 0.29) in identifying patients who developed MACE.
- SLECRISK identified more younger patients with fewer traditional risk factors as high-risk.
Conclusions:
- SLECRISK offers better agreement between predicted and observed cardiovascular events in SLE patients.
- SLECRISK's higher sensitivity is crucial for identifying at-risk individuals, potentially preventing adverse outcomes.
- SLECRISK is a valuable disease-specific tool for cardiovascular risk stratification in SLE.
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