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Properties of glycine-activated conductances in rat brain neurones
O A Krishtal1, Osipchuk YuV, S V Vrublevsky
1A.A. Bogomoletz Institute of Physiology, Ukrainian Academy of Sciences, Kiev, U.S.S.R.
Abstract:
The inhibitory responses to glycine, taurine, beta-alanine, 2-amino-5-phosphonovaleric acid (APV) were investigated in freshly isolated neurones from medulla oblongata and hippocampus of rat using concentration clamp, voltage clamp and intracellular perfusion techniques. All substances, when applied in a steplike manner, induced a rapid increase in the chloride permeability of the cellular membrane which slowly desensitized. The responses to all substances were blocked by external strychnine. Cross-desensitization experiments demonstrated that all substances tested activate the same system of membrane receptors.