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[ROLE PHOSPHOINOSITID SIGNALING PATHWAY IN OPIOIDS CONTROL OF P2X3 RECEPTORS IN THE PRIMARY SENSORY NEURONS]

V B Kulyk, I V Chizhmakov, T M Volkova

    Fiziolohichnyi Zhurnal (Kiev, Ukraine : 1994)
    |November 11, 2015
    PubMed
    Summary

    Opioid receptor activation in primary pain-sensing neurons has dual effects on P2X3 receptors. These opposing actions, involving the PLC pathway, may explain how opioids shift from pain relief to pain enhancement.

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