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Published on: December 30, 2014
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THE PECULIARITIES OF ARGINASE PATHWAY OF L-ARGININE IN SPERMATOZOA IN MEN WITH DIFFERENT FORMS OF PATHOSPERMIA
Fiziolohichnyi Zhurnal (Kiev, Ukraine : 1994)
|September 12, 2018
Summary
Arginase activity in sperm is reduced in infertile men, suggesting L-arginine metabolism inhibition. This may be an adaptive response to limit nitric oxide production and protect sperm health.
Area of Science:
- Reproductive Biology
- Andrology
- Biochemistry
Background:
- Male infertility affects a significant portion of couples trying to conceive.
- Pathospermia encompasses various sperm quality defects impacting fertility.
- L-arginine metabolism and its role in sperm function are crucial for male reproductive health.
Purpose of the Study:
- To investigate arginase activity in spermatozoa of infertile men with different forms of pathospermia.
- To analyze the hormonal profile in infertile men with pathospermia.
- To understand the relationship between arginase activity, hormonal changes, and sperm parameters.
Main Methods:
- Assessed arginase activity in spermatozoa from infertile men.
- Measured peripheral blood hormonal profiles (gonadotropins, sex hormones).
- Correlated arginase activity with sperm concentration in oligozoospermia.
Main Results:
- Arginase activity was significantly decreased in oligozoospermia, antenozoospermia, oligoasthenozoospermia, and leucocytospermia.
- Leukocytospermia showed the most pronounced decrease in arginase activity, linked to oxidative stress.
- Hormonal profile changes, particularly in follicle-stimulating hormone and testosterone, were observed across different pathospermia types.
Conclusions:
- Inhibition of the arginase pathway in spermatozoa appears to be an adaptive mechanism in infertile men.
- This inhibition may limit L-arginine availability and prevent excessive nitric oxide formation, protecting sperm.
- Sperm arginase activity is positively correlated with sperm concentration in men with oligozoospermia.
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